Fasting until Friday

Autophagy is an amazing process….

Autophagy fasting, a dietary approach, involves fasting to stimulate autophagy, a cellular process where cells break down and recycle damaged components to generate energy and building blocks. This process is triggered by nutrient deprivation, leading to the body utilizing stored resources for energy. 

Here’s a more detailed explanation:

What is Autophagy?

  • Autophagy is a natural cellular process where cells break down and recycle damaged or unnecessary components, like proteins and organelles, to generate energy and building blocks for new cell parts.
  • It’s like a “cellular recycling” system, ensuring the body can function efficiently, especially during times of stress or nutrient scarcity.
  • Autophagy is believed to be important for maintaining cellular health and preventing the buildup of harmful substances. 

How Fasting Stimulates Autophagy

  • Nutrient Deprivation:When you fast, your body experiences a reduction in nutrient intake, which signals the cells to activate autophagy. 
  • Energy Conservation:During a fast, the body enters a “survival mode” and conserves energy by breaking down and recycling cellular components through autophagy. 
  • Hormonal Changes:Fasting influences hormonal signaling pathways, such as insulin and glucagon, which can trigger autophagy. 
  • Ketosis:Prolonged fasting can lead to ketosis, where the body starts burning fat for energy, which is another factor that can stimulate autophagy. 

Benefits of Autophagy

  • Cellular Repair:Autophagy helps remove damaged or dysfunctional cellular components, promoting cellular repair and preventing the buildup of harmful substances.
  • Energy Efficiency:By recycling cellular components, autophagy can help the body conserve energy and function more efficiently, especially during times of nutrient scarcity.
  • Potential Health Benefits:Some research suggests that autophagy may have beneficial effects on overall health, including potentially reducing the risk of certain diseases and promoting longevity.
  • Neuroprotection:Autophagy plays a role in clearing out damaged proteins and other cellular debris in the brain, which is important for maintaining brain health and potentially preventing neurodegenerative diseases. 

Types of Fasting for Autophagy

  • Intermittent Fasting:This involves cycling between periods of eating and fasting, which can stimulate autophagy. 
  • Calorie Restriction:Reducing calorie intake can also trigger autophagy, as the body is forced to rely on its own resources for energy. 
  • Extended Fasting:Longer periods of fasting, such as 24-48 hours or even longer, can lead to more robust autophagy responses. 

#Fasting
#autophagy
#Health

The signal Trump Scandal continues

March 27, 2025

From Heather Cox Richardson

Today, Wired reported that it had found four more Venmo accounts associated with the Trump administration officials who participated in the now-infamous Signal chat about a planned military attack on the Houthis in Yemen. A payment on one of them was identified only with an eggplant emoji, which is commonly used to suggest sexual activity.

The craziness going on around us in the first two months of the second Trump administration makes a lot more sense if you remember that the goal of those currently in power was never simply to change the policies or the personnel of the U.S. government. Their goal is to dismantle the central pillars of the United States of America—government, law, business, education, culture, and so on—because they believe the very shape of those institutions serves what they call “the Left.”

Their definition of “the Left” includes all Americans, Republicans and Independents as well as Democrats, who believe the government has a role to play in regulating business, providing a basic social safety net, promoting infrastructure, and protecting civil rights and who support the institutional structures Americans have built since World War II.

In place of those structures, today’s MAGA leaders intend to create their own new institutions, shaped by their own people, whose ideological purity trumps their abilities. As Vice President J.D. Vance explained in a 2021 interview, he and his ilk believe that American “conservatives…have lost every major powerful institution in the country, except for maybe churches and religious institutions, which of course are weaker now than they’ve ever been. We’ve lost big business. We’ve lost finance. We’ve lost the culture. We’ve lost the academy. And if we’re going to actually really effect real change in the country, it will require us completely replacing the existing ruling class with another ruling class…. I don’t think there’s sort of a compromise that we’re going to come with the people who currently actually control the country. Unless we overthrow them in some way, we’re going to keep losing.” “We really need to be really ruthless when it comes to the exercise of power,” he said.

This plan is central to Project 2025, the plan President Donald Trump insisted before the election he knew nothing about but which, now that he’s in office, has provided the blueprint for a large majority of the administration’s actions. Project 2025 author Russell Vought, who is now Trump’s director of the Office of Management and Budget, called for a “conservative President” to “use…the vast powers of the executive branch” aggressively “to send power away from Washington and back to America’s families, faith communities, local governments, and states.”

Last month, journalist Gil Duran of The Nerd Reich noted that Curtis Yarvin, a thinker popular with the technological elite currently aligned with the religious extremists at Project 2025, laid out a plan in 2022 to gut the U.S. government and replace it with a dictatorship. This would be a “reboot” of the country, Yarvin wrote, and it would require a “full power start,” a reference to restarting a stalled starship by jumping to full power, which risks destroying the ship.

Yarvin called for “giving absolute sovereignty to a single organization,” headed by the equivalent of the rogue chief executive officer of a corporation who would destroy the public institutions of the democratic government. Trump—whom Yarvin dismissed as weak—would give power to that CEO, who would “run the executive branch without any interference from the Congress or courts…. Most existing important institutions, public and private, will be shut down and replaced with new and efficient systems.” Once loyalists have replaced civil servants in a new ideological “army,” the CEO “will throw it directly against the administrative state—not bothering with confirmed appointments, just using temporary appointments as needed. The job of this landing force is not to govern.” The new regime must take over the country and “perform the real functions of the old, and ideally perform them much better.” It must “seize all points of power, without respect for paper protections.”

Earlier this month, Yarvin cheered on the idea of hacking existing infrastructure “to operate in an unusual way that its designers, its previous operators, or both, did not expect,” and complimented DOGE for the way it has hacked into existing bureaucracies. The key performance indicator of DOGE, he wrote, “is its ability to take power from the libs, then keep it.”

Far from saving money for the United States, as Jacob Bogage at the Washington Post reported on March 22, billionaire Elon Musk’s “Department of Government Efficiency” has cost the government $500 billion, 10% of what the Internal Revenue Service took in last year. Bogage reports that the administration has demolished the IRS, firing nearly 20,000 employees, especially in the divisions that focus on enforcement, and dropping investigations of corporations and the richest taxpayers. Officials project that these changes will result in more tax evasion, and they are expecting a sharp drop in tax revenue this spring.

If the administration is working not to save money but rather to destroy the government, the cuts that threaten the well-being of American citizens make more sense. Today, Emily Davies and Jeff Stein of the Washington Post reported that Trump officials are looking for cuts of between 8% and 50% of the employees in federal agencies. They obtained an internal White House document that calls for the Department of Housing and Urban Development to be cut in half, the Interior Department to lose nearly 25% of its workforce, and the Internal Revenue Service to lose about one third of its people. The Justice Department is set to lose 8% of its workforce, the National Science Foundation 28%, the Commerce Department 30%, and the Small Business Administration 43%.

Cuts to the government have led to the Social Security Administration’s website crashing four times in ten days this month, and there are not enough workers to answer phones. Yesterday, Sahil Kapur and Julie Tsirkin of NBC News reported that lawmakers, including Senate Finance subcommittee on Social Security chair Chuck Grassley (R-IA), have been kept in the dark as the men working for DOGE have cut SSA phone services and instituted new rules requiring that beneficiaries without access to the internet prove their identity with an in-person visit to an SSA office.

Washington Post reporters Lisa Rein and Hannah Natanson warn that “Social Security is breaking down.” Senator Angus King (I-ME) told them: “What’s going on is the destruction of the agency from the inside out, and it’s accelerating…. What they’re doing now is unconscionable.”

In a televised Cabinet meeting on Monday, Homeland Security Secretary Kristi Noem said she planned to “eliminate FEMA,” the Federal Emergency Management Agency that responds to national emergencies like hurricanes. This news comes on top of Trump’s executive order last week calling for the Department of Education to be shuttered, along with cuts of about half of its workforce.

Yesterday, Apoorva Mandavilli, Margot Sanger-Katz, and Jan Hoffman reported in the New York Times that the Department of Health and Human Services (HHS) has suddenly cancelled more than $12 billion in federal grants to states. That money supported mental health services, addiction treatment, and programs to track infectious diseases. Today HHS announced it will be cutting 10,000 employees on top of the 10,000 who have already left and the more than 5,000 probationary workers who were fired last month. These cuts will include 3,500 full-time employees from the U.S. Food and Drug Administration and 2,400 employees from the U.S. Centers for Disease Control and Prevention.

In addition to slashing and burning through government agencies, the administration is trying to undermine the rule of law. Trump has signed executive orders suspending security clearances for law firms that represent Democratic clients and barring the government from hiring employees from those firms.

Trump and his team have challenged the judges who have ruled against Trump, working to destroy faith in the courts. House speaker Mike Johnson (R-LA) has suggested that Republicans in Congress could eliminate some federal courts, telling reporters: “We do have the authority over the federal courts, as you know. We can eliminate an entire district court. We have power of funding over the courts and all these other things.”

Trump’s administration is also working to take over colleges and universities, beginning with a high-profile fight against Columbia University in which the administration withheld $400 million in grants, allegedly over antisemitism at the school, until the university bent to the administration’s will. Columbia’s leaders did so, only to have the administration say the changes are only “early steps” and that Columbia “must continue to show they are serious in their resolve to end anti-Semitism…through permanent and structural reform. Other universities…should expect the same level of scrutiny and swiftness of action if they don’t act to protect their students and stop anti-Semitic behavior on campus,” a member of the administration said.

Chillingly, on Tuesday federal authorities in plain clothes took Tufts University international student Rumeysa Ozturk into custody on the street in Somerville, Massachusetts, saying she had “engaged in activities in support of Hamas,” apparently a reference to a pro-Palestinian op-ed she had written for the Tufts newspaper. On Wednesday the Department of Homeland Security said she was being held at an Immigration and Customs Enforcement center in Louisiana.

The administration is also working to reshape American culture according to their vision. The project of stripping words like “climate crisis,” “diversity,” “health disparity,” “peanut allergies,” “science-based,” “segregation,” “stereotypes,” and “understudied” from government communications are an explicit attempt to reshape the way Americans think. Today, in an executive order “restoring truth and sanity to American history,” Trump tried to change the ways in which Americans understand our history, too. He called for Vance, who as vice president serves on the Smithsonian Board of Regents, “to work to eliminate improper, divisive, or anti-American ideology from the Smithsonian and its museums, education and research centers, and the National Zoo.”

The problem for those who embrace this vision of America is that it is not popular. Before the election, only 4% of voters liked Project 2025, and it has not gained in popularity as the dramatic cuts to the government have hurt farmers by killing grain purchases for foreign aid, cut funding for cancer research, and thrown people out of work. Because Republican-dominated counties rely more heavily on government programs than Democratic-dominated counties do, cuts to government services are hitting Republican voters particularly hard.

On Tuesday, Democrat James Andrew Malone won a special election for a state senate seat in a Pennsylvania district that Trump won in November with 57% of the vote. Today, Trump was forced to withdraw New York Republican representative Elise Stefanik’s name from consideration for ambassador to the United Nations out of concern that a Democrat might win her vacant seat, although Trump won her district in 2024 by 21 points.

#Trump

I’m feeling old today

Today (27/03/2025) I’m feeling old. Its a nice day for this time of year. 17C at the moment which is nice. I’ve been gardening for most of the day both here at home and at my neighbours house where I spent an hour and a quarter cutting grass and weeding. After that I’ve been tweaking our garden spraying for greenfly and other stuff you’d probably not notice but when things start flowering it’ll make a nice display.
After all that I’ve just been for a short walk around our estate; probably no more than a mile and a half. I just feel tired. I should add I’m fasting today. My last meal was fish and chips last night at “Deep Blue” in Drayton with Val and friends Paul and Gilly….My next meal will be tomorrow morning sometime…

Check out this Flyover of my walk on Strava: https://strava.app.link/ZHAzuLfb5Rb

I find it difficult

I find it difficult to find things to write about. There is so much happening around me and its always difficult to decide what I should put to my journal. Today (26/03/2025) our Chancellor of the Exchequer brought a whole new range of measures to Parliament which she assured the house would put the country back on its feet. In my opinion its 50/50.

From BBC news

Chancellor Rachel Reeves has set out her plans for the UK economy during her Spring Statement in the House of Commons.

It came as the Office for Budget Responsibility (OBR) – which monitors the government’s spending plans – unveiled its latest economic forecasts.

Here is a summary of the main points.

Welfare changes

  • Health-related universal credit for new claimants, which was already due to be cut from £97 to £50 per week from April 2026 under measures announced last week, will now not rise with inflation until after 2030
  • Under-22s will no longer be able to claim the health-related element of universal credit
  • As outlined last week, for existing claimants health-related payments will be frozen at £97 per week until 2030, with a new top-up payment introduced for those with the most severe conditions
  • The standard allowance for universal credit will rise by £14 a week by 2030, instead of £15 a week as announced last week
  • There will also be a stricter eligibility test for personal independence payments (Pips), the main disability benefit, from November 2026

Economic forecasts

  • The Office for Budget Responsibility (OBR) has downgraded predicted growth for this year from 2% to 1%
  • But it has upgraded estimated growth for the next four years, to 1.9% next year, 1.8% in 2027, 1.7% in 2028 and 1.8% in 2029
  • The chancellor says this means the OBR is predicting the economy will be larger by the end of the forecast compared with what it was predicting at the time of her Budget last October
  • Inflation is forecast to average 3.2% this year, up from 2.6% previously forecast, before falling back to 2.1% in 2026 and then hitting the government’s 2% target in 2027

Housing

  • The OBR has estimated changes to England’s planning system announced last year will boost housebuilding by 170,000 over five years
  • The changes are forecast to grow the size of the economy by 0.2% by 2030, and 0.4% by 2035
  • £625m will be spent in England over four years to boost existing schemes to train workers in the construction sector

https://flo.uri.sh/visualisation/21845057/embed?auto=1

Spending rules

  • The OBR says that without action, the government would have missed its spending rule – for taxes to cover day-to-day expenditure in 2030 – by £4.1bn
  • It says cuts and extra tax from the planning changes mean a £9.9bn financial buffer against that rule, which had been wiped out by higher debt costs since the Budget, should be restored by 2030
  • The forecaster says there is now a 54% chance the government will meet its spending rule, up slightly from a 51% likelihood in October
  • The chance of meeting the government’s other rule, for public debt to be projected to be falling as a share of the economy, remains unchanged at 51%

Defence and overseas aid

  • Defence spending, which had been due to rise £2.9bn next year, to increase by a further £2.2bn
  • The Treasury says this will take military expenditure to 2.36% of national income next year, a “down payment” on plans to raise it to 2.5% by 2027
  • Ministers say the spending will be funded by reducing overseas aid from 0.5% to 0.3% of gross national income in 2027, and from the Treasury’s reserves

Public services

  • Day-to-day government spending to fall by £6.1bn per year by 2030, growing by 1.2% in real terms (after taking account of inflation) after 2026, instead of 1.3%
  • Target to reduce the administrative costs of government departments by 15% by 2030
  • About 10,000 civil service jobs are expected to go, including staff working in HR, policy advice, communications and office management

Other measures

  • A pledge to hire 400 more HMRC staff to tackle “wealthy offshore non-compliance” – estimated to bring in an extra £500m over five years
  • A new US-style scheme to be launched later this year, under which tax avoidance “informants” will get a slice of any money recovered

ZOE re visited (ongoing post)

Its 3 and a bit months since I was enrolled in ZOE and I have to admit it does become a little compulsive. Its coming up to my second test and I was expecting that I would only get an opportunity to get the “poo” test but low and behold a couple of days ago I received an email from ZOE asking if I would like to do a complete test which would be like the initial test….. I have no idea why I received the invite but why wouldn’t I?

My pack to start the retest is arriving this morning (2025 02 02). I’m excited… Why wouldn’t I be.

#revisitZOE.
#ZOE
#ZOEretest

My friends Martin and Donna

My friends Martin and Donna do some really interesting travelling and write posts on Facebook which quite a few people follow. I have suggested to them that although they write good stuff its condemned to disappear into the depths of the FACEBOOK hole in the ground. I have suggested they set up a blog of their travels that friends can go back to to see restaurants, hotels and places they have reviewed at a later date… Its simple and they get a nice record with pictures they can go back to at any time…. I would certainly value it

I don’t think it’ll happen. Martin doesn’t change very easily 😉

I’ve added a screenshot of one of Martin’s last posts. I’m hoping he won’t mind. I’ll take it down if he disapproves 😉

#martinanddonna

#travellog

What’s going on in the US

I’m very concerned as are many other about what’s going on in the world with particular reference to the USA, only because the USA has such a profound influence on the rest of the world.

The election for a second term of Donald Trump is scary. We are seeing the world stock exchanges taking a tumble since his election. The POTUS has put a non elected billionaire (Elon Musk) into a hugely powerful position where he has the power to go into govt offices and sack people on the spot. Apparently this is unlawful and US judges are fighting against it.

Yesterday several members of Trump’s cabinet shared plans on “Signal” for an attack on Houti people with a newspaper editor of a US paper (Atlantic) against all protocols set by previous set ups

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Are you worried about this?

#TroubleintheUSA

#JDVanceIsDangerous

#USA